I’ve read some great self-published books, and I’ve also read my share of badly-wriiten ones. On the average, I find that the self-published books are not as well written as the commercially-published books. I feel that if you want your book to be in the hands of more readers, and get His message out there, then you need to try to find a commercial publisher to publish your work. However, if you have a unique subject matter, and you can’t find a commercial publisher to publish you, then you may consider self-publishing. However, I’d recommend getting a GOOD editor to help with the process.
However, if you feel the Lord is leading you to self-publish, then my all means, let the Spirit guide you.
Trying to find a commercial publisher for your work is hard, that’s why it’s important to attend writers conferences, and if you write fiction, you might want to consider joining American Christian Fiction Writers (ACFW). They have an awesome conference every September, and you can connect with other published writers as well as editors of major Christian publishing houses.